pharmachologic effect

Tetrizoline is an adrenergic agonist that stimulates ?-adrenergic receptors of the sympathetic nervous system, but does not have or has a weak effect on ?-adrenergic receptors. Being an adrenomimetic amine, tetrizoline has a vasoconstrictor effect and reduces tissue edema.
The effect begins 60 seconds after instillation and lasts 4-8 hours.
Indications

To relieve edema and hyperemia of the conjunctiva (redness of the eyes) caused by the effects of chemical and physical factors (smoke, wind, dust, chlorinated water, light, cosmetics, contact lenses), as well as those arising from allergic reactions such as hay fever.
Method of administration and dosage

The drug is used topically.
Adults and children over 2 years old are instilled 1 drop 2-3 times / day.
The use of the drug for more than 4 days should be carried out only under the supervision of a physician.
The drug should be used only according to the indications, the route of administration and the doses indicated in the instructions.
Side effects

Postmarketing data
Adverse reactions are classified according to the following gradation of frequency of occurrence: very often (> 1/10), often (> 1/100, <1/10), infrequently (> 1/1000, <1/100), rarely (> 1/10 000, <1/1000), very rare (<1/10 000, including individual messages), the frequency is unknown (the frequency of occurrence cannot be estimated from the available data).

    From the side of the organ of vision: the frequency is unknown - dilation of the pupil, blurred vision.
    Local reactions: frequency unknown - reactions at the injection site (including a burning sensation in the eye area, redness, irritation, swelling, pain, itching).

It is assumed that the frequency, type and severity of adverse reactions in children are similar to those observed in adults.
If the patient has side effects indicated in the instructions, or they are aggravated, or any other side effects are noted that are not indicated in the instructions, it is necessary to inform the doctor about this.

Contraindications

    angle-closure glaucoma;
    children under 2 years old;
    hypersensitivity to the components of the drug.

With care: patients with severe cardiovascular diseases (coronary artery disease, arterial hypertension, aneurysms); pheochromocytoma; hyperplasia of the prostate gland; hyperthyroidism; diabetes mellitus; porphyria; dry rhinitis; dry keratoconjunctivitis; glaucoma; patients receiving MAO inhibitors or other drugs that can increase blood pressure; elderly patients; during pregnancy and during breastfeeding.

Overdose

When used in accordance with the instructions, the risk of overdose is minimal. However, if accidentally ingested (swallowed), the following overdose symptoms are possible: pupil dilation, nausea, cyanosis, fever, convulsions, tachycardia, arrhythmia, cardiac arrest, arterial hypertension, pulmonary edema, respiratory depression (including respiratory arrest), depression of central nervous system function (including the development of drowsiness and coma).
The risk of developing overdose symptoms due to systemic effects of the drug is high in newborns and young children, especially if swallowed.
Treatment: if it enters the gastrointestinal tract, activated charcoal, gastric lavage, oxygen inhalation, antipyretic and anticonvulsant drugs are prescribed. To lower blood pressure, phentolamine 5 mg in saline is used slowly intravenously or 100 mg orally. Vasopressor drugs are contraindicated in patients with low blood pressure. The specific antidote is unknown.
If any of the symptoms of an overdose described above appear, the patient should immediately consult a doctor.
special instructions

Contact lenses should be removed before instilling the drug and reinstalled after 15 minutes. It is necessary to avoid direct contact of the drug with soft contact lenses due to the possible violation of their transparency.
It is possible to develop reactive hyperemia of the conjunctiva and nasal mucosa (rhinitis medicamentosa) if the instructions for use are not followed.
If within 72 hours the condition does not improve or irritation and hyperemia persist or increase, the drug should be discontinued and a doctor should be consulted. In case of intense pain in the eyes, severe acute or one-sided redness of the eyes, headache, blurred vision, the appearance of spots before the eyes or double vision, the patient should immediately consult a doctor.
Long-term use of the drug can increase flushing or lead to its reappearance.
If irritation or redness is caused by diseases of the organ of vision: infection, foreign body or chemical trauma to the cornea, consult a doctor before use.
The use of the drug may cause temporary dilation of the pupil. Long-term use and overdose of the drug should be avoided, especially in children.
Do not use the drug if its color changes or becomes cloudy.
Topical application of sympathomimetic amines into the conjunctival sac, as a result of pupil dilation, may

sometimes lead to a violation of intraocular pressure in persons predisposed to this.
If a medicinal product has become unusable or the expiration date has expired, it should not be poured into wastewater and thrown out into the street, it should be placed in a bag and put in a trash can. These measures will help protect the environment.
Use in pediatrics
Safety studies in children and adolescents have not been conducted.
Influence on the ability to drive vehicles and control mechanisms
In rare cases, after using the drug, blurred vision occurs, which can affect the ability to drive vehicles and mechanisms.
Interaction with other drugs

The drug should not be used concomitantly with MAO inhibitors such as tranylcypromine, tricyclic antidepressants, and drugs that increase blood pressure. Combined use with these groups of drugs can lead to an increase in the vasoconstrictor effect and an increase in blood pressure.
If the patient is using the above or other drugs (including over-the-counter), consult a doctor before using VisOptics.
Storage conditions

The drug should be stored in its original packaging out of the reach of children at a temperature of 15 ° to 25 ° C. The shelf life is 5 years. After opening the bottle, the drops should be used within 4 weeks.