Compare to Afrin Original active ingredient. Equate Original 12 hour Nasal Spray provides fast, powerful congestion relief for allergies and colds. Each dose delivers Oxymetazoline Hydrochloride, the number one doctor recommended adult nasal spray active ingredient (of U.S. physicians surveyed by an independent market research firm). This spray shrinks swollen nasal membranes so you can breathe more freely, temporarily relieves sinus congestion and pressure, and temporarily relieves nasal congestion due to: common cold, hay fever, or upper respiratory allergies. This nasal spray clears stuffy nose fast, and provides maximum strength congestion relief. It soothes as it relieves. Gluten free.